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Estrogen is a woman’s most important hormone. Without hormone replacement therapy, the loss of estrogen puts her at increased risk for premature ovary failure, osteoporosis, heart disease, colon cancer, Alzheimer’s disease, tooth loss, impaired vision, Parkinson’s disease and diabetes. The longer a woman is without the protection of her own estrogen, the greater the risk for serious health consequences of these conditions.

There are estrogen receptors in a variety of organs throughout the body and brain. That’s why hormonal imbalance produces different symptoms such as loss of skin elasticity, bone shrinkage, mood and cognitive decline. On the other hand, when estrogen levels rise as they do in the first week of menses, their overall effect is to increase the amount of serotonin available in the spaces between the brain’s nerve cells. That improves mood. Within the brain, estrogen may in fact act as a natural antidepressant and mood stabilizer. Therefore, it is essential that a woman suffering from premature ovary failure or surgical menopause receive treatment from a HRT physician who understands the many ramifications of the disease and is willing and able to meet her endocrine and emotional needs.

Testosterone hormone therapy gives a woman her mental clarity, libido and muscle tone and mass. When this hormone is at low levels, women often complain of mental confusion, weight gain and poor muscle growth even with regular exercise.

The effect of hormone deficiency on the brain, muscle, bone, heart and metabolism can be significant without hormone replacement therapy for women and dangerous to long term health. The brain needs normal amounts of testosterone in balance with estrogen to produce serotonin, which supports emotional balance. When lacking in these hormones, a woman will experience emotional instability that often results in increased anxiety, irritability, sleep disturbances, anger, sadness and depression.